Applications of Diphenyl N,N'-Diisopropylphosphoramidite
Dibenzyl Diisopropylphosphoramidite, more commonly known by its systematic name, is an important organophosphorus compound.Item DetailsChinese Name:Diphenyl N,N'-diisopropylphosphoramidite (also commonly called: Dibenzyl Diisopropylphosphoramidite)English Name:Dibenzyl DiisopropylphosphoramiditeCAS Numbe:108549-23-1Molecular Formula:C₂₀H₂₈NO₂PMolecular Weight:345.42 g/molAppearance:Colorless to pale yellow oily liquidCharacteristics:Air- and moisture-sensitive; typically requires sealed storage at 2-8°CPrimary ApplicationsDibenzyl Diisopropylphosphoramidite plays a key role in organic synthesis and materials science, primarily serving as a phosphoramidation reagent and organic synthetic intermediate.Pharmaceutical and Chemical Industry:Antibiotic Synthesis: It is used as a phosphorylating reagent in the process of preparing the antibiotic Tedizolid Phosphate. The use of this reagent can effectively avoid the generation of by-products, improve reaction yield, and make the process more aligned with green chemistry principles.
Functional Nucleic Acid Synthesis: This reagent can be used to prepare nucleic acids containing photosensitive units. It demonstrates high reactivity, good stability, and photoresponsiveness in reactions, providing a concise and efficient method for the functionalization of nucleic acids.Materials Science:Preparation of Bioactive Coatings: In medical device manufacturing, it is used to create silicon- and copper-loaded titanium dioxide antibacterial bioactive film layers on nanostructured titanium surfaces. This coating can impart powerful antibacterial properties and wear resistance to implanted titanium plates, thereby improving surgical success rates.
推荐文章
-
This article is sourced from The Lancet regional health AmericaThe 85th Scientific Sessions of the American Diabetes Association (ADA) was held in Chicago, IL, USA, from June 20 to June 23, 2025. Below is a summary of topics covered in some of the most exciting sessions.A comparison of the benefits of newer drugs for type 2 diabetesIn this session, Dr. Karol Watson (University of California, Los Angeles, CA, USA) discussed the benefits of glucagon-like peptide-1 receptor agonists (GLP-1 RAs). According to Dr. Watson, to date, there is no strong evidence that dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 RAs improve cardiovascular disease. In contrast, there is compelling evidence supporting the benefit of GLP-1 RAs on reducing stroke, mortality, and kidney disease. Dr. Watson emphasized that sodium-glucose co... -
This article is sourced from The Lancet MicrobeNov 18–24, 2025, marks the 10th edition of World AMR Awareness Week, an annual campaign led by WHO with the goal to increase awareness of global antimicrobial resistance (AMR) and to encourage best practices. Much has happened over this past decade—a pandemic, a seminal paper directly attributing over 1 million deaths each year to bacterial AMR, and a shift to One Health thinking—but the next decade will be pivotal in translating awareness into sustained action, innovative solutions, and global leadership to truly curb the threat of AMR.Despite increasing global awareness, progress in combating AMR has been slow. Two WHO reports, published on Oct 2, describe how the pipelines of antibacterial agents and bacterial diagnostics remain insufficient to meet urgent global needs. Both reports ca...
-
Synthesis and characterization of the dental adhesive monomer 10-MDP Author links open overlay panelPaula Roberta Perondi Furtado, Rafael Minski Savanhago, Nataly Castro, Rogerio Aparecido Gariani, Marcia Margarete Meier Show more Add to Mendeley Share Cite https://doi.org/10.1016/j.dental.2024.09.009Get rights and content Abstract Many studies have demonstrated the excellent performance of 10-MDP (10-methacryloyloxydecyl dihydrogen phosphate) as a functional monomer for dental adhesive materials and as a primer for ceramic surfaces. Although adhesive performance is affected by the purity level of 10-MDP, this parameter is rarely described, and possible byproducts have been suggested in the literature, but have not been identified to date. The present study aims to present an ac...
